Ongoing Funded Research
- Title: Immediate Effects of Therapeutic Group Drumming on Affective Stress and Biomarkers of Stress
Funding: RayBiotech
Amount: $1,500
Role: Principal Investigator
Summary: While group drumming has shown promise for reducing stress and enhancing social bonds, our pilot study (n=34) suggests that age, prior music experience, and academic status may shape how college students respond to this intervention. Based on these findings, we are investigating how a short, community-focused drumming impacts mood and physiological markers of stress. This multi-level analysis will help us determine whether drumming benefits all students similarly or by specific subgroups. - Title: Educational Biomarker Discovery Lab
Funding Agency: Private Funding
Role: Principal Investigator
Summary: The Educational Biomarker Discovery Lab (EBDL) is an interdisciplinary research and teaching initiative dedicated to training the next generation of scientists in biomarker discovery and its applications to environmental, respiratory, and immunology health. The lab integrates cutting-edge methodologies in biochemistry, immunology, environmental health, and computational approaches to investigate environmental exposures and health disparities. EBDL emphasizes experiential learning and mentorship, particularly for students from underrepresented backgrounds, fostering skills in both research and science communication. The lab's mission is to advance scientific understanding of health disparities while preparing students for impactful careers in biomedical and public health research. - Title: All of Us Program
Funding Agency: NIH
PI: NA
Role: Investigator with Registered and Controlled Tier Access
Summary: As a user and investigator within the NIH All of Us Research Program Workbench, I leverage this expansive and diverse dataset to explore health disparities, with a focus on identifying biomarkers linked to respiratory and immunological health outcomes. My role involves utilizing advanced computational and bioinformatics tools to analyze multidimensional data, contributing to a deeper understanding of the intersection between environmental exposures and health equity. Through this work, I aim to generate actionable insights that address public health challenges while promoting inclusive and representative biomedical
research. - Title: Endemic Outdoor Aeroallergens and the Incidence of Respiratory Viral Diseases in Puerto Rico
Funding Agency: Puerto Rico Public Health Trust
PI: Benjamín Bolaños-Rosero
Amount: $10,000
Role: Collaborator and graduate student mentor
Summary: The objective of this study is to determine the role of outdoor fungal spores, which aeroallergens endemic in the atmosphere of Puerto Rico, in the incidence and immunological susceptibility to COVID-19 in Puerto Rico. Also, this project seeks to demonstrate the utility of an innovative blood microsample approach to determine immunological risks to emerging respiratory health pathogens, such as the SARS-CoV-2 virus. The expected impact of this project is that it will provide data on immunological risks to emerging respiratory health hazards from exposures to endemic biological aerosol.
Completed Funded Research
- Title: Research on the Epidemiology of SARS-CoV-2 among Essential Response
Personnel (RECOVER)
Funding Agency: Center for Disease Control and Prevention
PI: Alberto Cabán-Martínez
Amount: $3,950,000 (three-year funding)
Role: Lead-Scientist, Co-Investigator
Summary: The objectives of the RECOVER study are to 1) determine the frequency of SARSCoV-2 virus infection and re-infection and COVID-19 illness among healthcare, first responders, and essential or frontline workers; and 2) estimate the effectiveness of COVID-19 vaccines and interventions. The anticipated impact of this project is that it will help measure the COVID-19 incidence, identify risk factors for infection and manifestation as symptomatic and asymptomatic, describe symptomatology and outcomes of infection and re-infection, medical-attendance, immune response, examine antibody correlates of protection against SARS-CoV-2 re-infection, duration of viral shedding, and assess knowledge, attitude and practices related to SARS-CoV-2 and COVID-19. - Title: Linking Microbial, SVOC and Pro-Inflammatory Exposures in Homes to Childhood Asthma Severity: A Community Filter Forensics Approach
Funding Agency: US Department of Housing and Urban Development
Project Number (and PI): HUD126513356
PI: Kerry Kinney
Amount Awarded: $700,000
Role: Collaborator, Sub-Award Principal Investigator ($76,931)
Summary: The purpose of this study was to evaluate the merits of using a Community Filter Forensics approach for assessing levels of indoor contaminants and pro-inflammatory potential in homes. In the original Filter Forensics HUD study, it was determined that heating, ventilation, and air conditioning (HVAC) filters can serve as integrated, long-term samples of particle-bound contaminants in a cohort of rural homes. Novel relationships were identified between the microbiome and 1) asthma triggers in home HVAC filter dust, and 2) the severity of asthma for children in these homes, including potentially protective exposures. In this follow-up study, the Filter Forensics approach was extended assess housing-related health hazards in a urban cohorts of households across three climate zones in Texas. The impact of this project and the Community Filter Forensic approach was that it allowed efficient collection of data to identify both potentially detrimental and protective home environmental exposures. - Title of Pilot Study: Immune and Epigenetic Signatures Related to Post-Hurricane Maria Indoor Contamination in Puerto Rico
Funding Agency: National Heart, Lung, and Blood Institute
Project Number: R25HL126140
PIs: Joe Garcia, Francisco Moreno, Sairam Parthasarathy
Amount Awarded: $14688 (Pilot Study under a training within project R25HL126140)
Role: PI of Pilot Study as part of the Advanced Respiratory Research for Equity (AIRE) training
program
Summary: The purpose of this study was to determine the immunological and epigenetic signatures that settle dust from homes with different magnitude of water damage from Hurricane Maria in Puerto Rico induced in peripheral blood leukocytes. The impact of this project was it will highlighted the immune and genetic modulating-potential from exposures to increased microbial contamination among Puerto Ricans expose the environmental hazards from Hurricane Maria, and preliminary data to design further studies on how increase indoor multi-pollutant foci affect the immune system of individuals living in areas susceptible to
extreme atmospheric events. - Title: Taking a Breath after the Disaster: Homes, Molds, and Health in Puerto Rico after Hurricane Maria
Funding Agency: National Institute of Environmental Health Sciences
Project Number: R21ES029762
PI: Humberto Cavallin-Calanche
Amount Awarded: $408, 316
Role: Collaborator, Sub-Award Principal Investigator ($15,500)
Summary: The purpose of this study was to immunological and respiratory health risks that long-term water damage to houses in Puerto Rico in the aftermath of Hurricane Maria. The objectives of the study were to 1) characterize the fungal communities present inside and outside water damage and non-flooded (control) homes in Puerto Rico following hurricane Maria and determine the change in these communities during the first two years following the Hurricane; 2) evaluate the pro-inflammatory potential of indoor air samples collected from the water-damage homes and compare these levels to those in non-flooded (control) study homes and outdoor air; 3) determine the relationship between occupant respiratory health and home characteristics including flood damage as well as the indoor fungal community and proinflammatory potential of dust in the homes. - Title: Genetic Susceptibility to Asthma and Indoor Air Pollution in Peru
Funding Agency: National Institute of Environmental Health Sciences
Project Number: 3R01ES018845-04S1
PI: Nadia Hansel
Amount Awarded: $410, 571
Role: Postdoctoral Collaborator (under Drs. Patrick Breysse and Thomas Hartung)
Summary: The purpose of this was to identify genetic variants associated with asthma and its associated traits (i.e., asthma severity, pulmonary function, airway inflammation) in relation to indoor air pollutant exposures in two Peruvian cities, Lima and Tumbes. The impact of this study was identifying candidate genes for asthma and associated traits relevant to both the general population as well as those contributing to disparities in asthma morbidity among individuals in Peru. Also, by identifying subgroups of the population who are particularly vulnerable to air pollution is an important objective, as the results can be used to identify people most likely to benefit from exposure avoidance.