Drosophila Model for Potential Plasticizer Induced Hyperactivity

Plasticizing additives such as phthalates, are known to cause disruptions in human nervous systems linked to neurological disorders, thus with the Drosophila activity monitoring (DAM) system test can be conducted to consider whether the flies are exhibiting hyperactivity (Hlisníková et al., 2021). Drosophila is a useful model for exposure of metabolic compounds followed by general and specific assays of their effects. Our experiments propose a link between exposure to phthalates and hyperactivity between humans that can be investigated with flies as a model for testing hyperactivity (Praveena et al., 2020). The link that is proposed is a cross-sectional study that collected urine samples of children and then scored kids based on attention-deficit/hyperactivity disorder (ADHD) (Kim et al., 2009). The DAM system is a method in which flies are individually monitored for activity during the day and night to notice any differences in general activity, locomotion, and circadian rhythms. The general activities of the flies would be examined alongside a baseline of Drosophila activity, alongside flies induced with glucose to measure any differences in hyperactivity. The addition of glucose is to give a baseline of what hyperactive flies will look like in their sleep cycle and movements in the DAM system We hypothesize a significant increase in hyperactivity in phthalate-exposed flies over both high-glucose and normal flies because phthalates are disrupters in the nervous system, thus may cause signs of hyperactivity when administered to the flies.