The Contributions of Previous Research on the Benefits and Future Treatments of Magnesium as an Implant Material

Bailey Sperry; Ariel J. Stateman; Jennifer Sutton; Félix E. Rivera-Mariani

doi:10.5281/ZENODO.1240423

The Contributions of Previous Research on the Benefits and Future Treatments of Magnesium as an Implant Material

Bailey Sperry
, Ariel J. Stateman
, Jennifer Sutton
, Félix E. Rivera-Mariani

Larkin University

Research output: Contribution to conference › Poster

Abstract

William Hunter proposed that damaged cartilage cannot be reconstituted. There is a more extensive availability of mesenchymal stem cells (MSC’s) highlights the attractiveness of their use in cartilage regeneration. After investigating the effects of magnesium on the nuclear translocation of nuclear factor-κB (NF-κB) induced by LPS and IFN-γ in RAW 264.7 (RAW) cells to validate its anti-inflammatory mechanism as well as the investigation of the chondrogenic differentiation of human bone marrow MSCs (hBMSCs) co-cultured with activated macrophage cell-conditioned medium and the potential effects of magnesium addition in the process, the following conclusion can be drawn: The use of Magnesium showed evidence of enhancing the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation. Purpose: To examine the potential effects of magnesium on the phenotypic changes in macrophages and their release of inflammatory cytokines with or without lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activation.

Original language	American English
DOIs	https://doi.org/10.5281/ZENODO.1240423
State	Published - May 3 2018
Externally published	Yes
Event	Inaugural Larkin University Research Symposium - Larkin University, Miami, United States Duration: May 2 2018 → May 3 2018

Symposium

Symposium	Inaugural Larkin University Research Symposium
Country/Territory	United States
City	Miami
Period	5/2/18 → 5/3/18

Keywords

magnesium
implant
macrophages
inflammation

Access to Document

10.5281/ZENODO.1240423License: CC BY

http://spiral.lynn.edu/facpubs/1424

Cite this

@conference{31e4669b75b84a089c0702aea429fdb5,

title = "The Contributions of Previous Research on the Benefits and Future Treatments of Magnesium as an Implant Material",

abstract = "William Hunter proposed that damaged cartilage cannot be reconstituted. There is a more extensive availability of mesenchymal stem cells (MSC{\textquoteright}s) highlights the attractiveness of their use in cartilage regeneration. After investigating the effects of magnesium on the nuclear translocation of nuclear factor-κB (NF-κB) induced by LPS and IFN-γ in RAW 264.7 (RAW) cells to validate its anti-inflammatory mechanism as well as the investigation of the chondrogenic differentiation of human bone marrow MSCs (hBMSCs) co-cultured with activated macrophage cell-conditioned medium and the potential effects of magnesium addition in the process, the following conclusion can be drawn: The use of Magnesium showed evidence of enhancing the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation. Purpose: To examine the potential effects of magnesium on the phenotypic changes in macrophages and their release of inflammatory cytokines with or without lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activation.",

keywords = "magnesium, implant, macrophages, inflammation",

author = "Bailey Sperry and Stateman, \{Ariel J.\} and Jennifer Sutton and Rivera-Mariani, \{F{\'e}lix E.\}",

year = "2018",

month = may,

day = "3",

doi = "10.5281/ZENODO.1240423",

language = "American English",

note = "Inaugural Larkin University Research Symposium ; Conference date: 02-05-2018 Through 03-05-2018",

}

TY - CONF

T1 - The Contributions of Previous Research on the Benefits and Future Treatments of Magnesium as an Implant Material

AU - Sperry, Bailey

AU - Stateman, Ariel J.

AU - Sutton, Jennifer

AU - Rivera-Mariani, Félix E.

PY - 2018/5/3

Y1 - 2018/5/3

N2 - William Hunter proposed that damaged cartilage cannot be reconstituted. There is a more extensive availability of mesenchymal stem cells (MSC’s) highlights the attractiveness of their use in cartilage regeneration. After investigating the effects of magnesium on the nuclear translocation of nuclear factor-κB (NF-κB) induced by LPS and IFN-γ in RAW 264.7 (RAW) cells to validate its anti-inflammatory mechanism as well as the investigation of the chondrogenic differentiation of human bone marrow MSCs (hBMSCs) co-cultured with activated macrophage cell-conditioned medium and the potential effects of magnesium addition in the process, the following conclusion can be drawn: The use of Magnesium showed evidence of enhancing the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation. Purpose: To examine the potential effects of magnesium on the phenotypic changes in macrophages and their release of inflammatory cytokines with or without lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activation.

AB - William Hunter proposed that damaged cartilage cannot be reconstituted. There is a more extensive availability of mesenchymal stem cells (MSC’s) highlights the attractiveness of their use in cartilage regeneration. After investigating the effects of magnesium on the nuclear translocation of nuclear factor-κB (NF-κB) induced by LPS and IFN-γ in RAW 264.7 (RAW) cells to validate its anti-inflammatory mechanism as well as the investigation of the chondrogenic differentiation of human bone marrow MSCs (hBMSCs) co-cultured with activated macrophage cell-conditioned medium and the potential effects of magnesium addition in the process, the following conclusion can be drawn: The use of Magnesium showed evidence of enhancing the chondrogenic differentiation of mesenchymal stem cells by inhibiting activated macrophage-induced inflammation. Purpose: To examine the potential effects of magnesium on the phenotypic changes in macrophages and their release of inflammatory cytokines with or without lipopolysaccharide (LPS) and interferon-γ (IFN-γ) activation.

KW - magnesium

KW - implant

KW - macrophages

KW - inflammation

U2 - 10.5281/ZENODO.1240423

DO - 10.5281/ZENODO.1240423

M3 - Poster

T2 - Inaugural Larkin University Research Symposium

Y2 - 2 May 2018 through 3 May 2018

ER -